Sertoli cell

(Redirected from Sertoli cells)
Jump to navigation Jump to search

Template:Infobox Anatomy

WikiDoc Resources for Sertoli cell

Articles

Most recent articles on Sertoli cell

Most cited articles on Sertoli cell

Review articles on Sertoli cell

Articles on Sertoli cell in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Sertoli cell

Images of Sertoli cell

Photos of Sertoli cell

Podcasts & MP3s on Sertoli cell

Videos on Sertoli cell

Evidence Based Medicine

Cochrane Collaboration on Sertoli cell

Bandolier on Sertoli cell

TRIP on Sertoli cell

Clinical Trials

Ongoing Trials on Sertoli cell at Clinical Trials.gov

Trial results on Sertoli cell

Clinical Trials on Sertoli cell at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Sertoli cell

NICE Guidance on Sertoli cell

NHS PRODIGY Guidance

FDA on Sertoli cell

CDC on Sertoli cell

Books

Books on Sertoli cell

News

Sertoli cell in the news

Be alerted to news on Sertoli cell

News trends on Sertoli cell

Commentary

Blogs on Sertoli cell

Definitions

Definitions of Sertoli cell

Patient Resources / Community

Patient resources on Sertoli cell

Discussion groups on Sertoli cell

Patient Handouts on Sertoli cell

Directions to Hospitals Treating Sertoli cell

Risk calculators and risk factors for Sertoli cell

Healthcare Provider Resources

Symptoms of Sertoli cell

Causes & Risk Factors for Sertoli cell

Diagnostic studies for Sertoli cell

Treatment of Sertoli cell

Continuing Medical Education (CME)

CME Programs on Sertoli cell

International

Sertoli cell en Espanol

Sertoli cell en Francais

Business

Sertoli cell in the Marketplace

Patents on Sertoli cell

Experimental / Informatics

List of terms related to Sertoli cell

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Template:Editor help

A Sertoli cell (a kind of sustentacular cell) is a 'nurse' cell of the testes which is part of a seminiferous tubule.

It is activated by follicle-stimulating hormone, and has FSH-receptor on its membranes.

Functions

Its main function is to nurture the developing sperm cells through the stages of spermatogenesis. Because of this, it has also been called the "mother cell." It provides both secretory and structural support.

Secretory

Sertoli cells secrete the following substances:

  • inhibin and activins - secreted after puberty, and work together to regulate FSH secretion
  • the Ets related molecule (ERM transcription factor) - needed for maintenance of the spermatogonial stem cell in the adult testis.

Structural

The junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. Sertoli cells control the entry and exit of nutrients, hormones and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site.

The cell is also responsible for establishing and maintaining the spermatogonial stem cell niche, which ensures the renewal of stem cells and the differentiation of spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of spermatozoa.

Other functions

During the Maturation phase of spermiogenesis, the Sertoli cells consume the unneeded portions of the spermatazoa.

Production of Sertoli cells

Once fully differentiated, the Sertoli cell is unable to proliferate. Therefore, once spermatogenesis has begun, no more Sertoli cells are created.

Recently however, some scientists have found a way to grow these cells outside of the body. This gives rise to the possibility of repairing some defects that cause male infertility.

Nomenclature

Sertoli cells are called so because of their eponym Enrico Sertoli, an Italian physiologist who discovered them while studying medicine in the University of Pavia, Italy. [2]

He published a description of this cell in 1865. The cell was discovered by Sertoli with a Belthle microscope purchased in 1862, which he used while studying medicine.

In the 1865 publication, his first description used the terms "tree-like cell" or "stringy cell" and most importantly he referred to these "mother cells." It was other scientists who used Enrico's family name, Sertoli, to label these cell in publications, starting in 1888. As of 2006, two textbooks that are devoted specifically to the Sertoli cell have been published.

Histology

On slides, using standard staining, it can be easy to confuse the Sertoli cells with the other cells of the germinal epithelium. The most distinctive of the Sertoli cells is the dark nucleolus.[3]

Pathology

Sertoli-Leydig cell tumour are part of the sex cord-stromal tumour group of ovarian neoplasms.

Additional images

References

  1. Xiong X, Wang A, Liu G, Liu H, Wang C, Xia T, Chen X, Yang K (2006). "Effects of p,p'-dichlorodiphenyldichloroethylene on the expressions of transferrin and androgen-binding protein in rat Sertoli cells". Environ Res. 101 (3): 334–9. PMID 16380112.
  2. Template:WhoNamedIt
  3. http://www.cvm.okstate.edu/instruction/mm_curr/histology/MR/HiMRP4.htm

External link

Template:Male reproductive system

de:Sertoli-Zelle it:Cellula del Sertoli he:תא סרטולי nl:Sertolicel simple:Sertoli cell


Template:WikiDoc Sources