Serotonin uptake inhibitor

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A serotonin uptake inhibitor is a drug which acts as a neurotransmitter uptake inhibitor on serotonin receptors.

The most well known members of this class are the selective serotonin reuptake inhibitors (SSRI)s. However, there also exist non-selective inhibitors. In some cases, such as the older antidepressants clomipramine and trazodone, this lack of selectivity is seen as a disadvantage, and is one of the reasons those drugs are currently prescribed less frequently. In other cases, such as duloxetine and milnacipran, the lack of selectivity is considered part of the normal profile of the medication, and it is classified accordingly.

Examples of serotonin uptake inhibitors include:[1]


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