Secretagogin

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Secretagogin is a protein that in humans is encoded by the SCGN gene.

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation. This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

Further reading

• Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein". Cereb. Cortex. 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas". Pituitary. 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
• Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
• Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
• Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release". EMBO Journal. 34: 36–54. doi:10.15252/embj.201488977. PMC 4291479.