SMG1 (gene)

PI-3-kinase-related kinase SMG-1
Identifiers
Symbols	SMG1 ; ATX; 61E3.4; KIAA0421; LIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56697
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

PI-3-kinase-related kinase SMG-1, also known as SMG1, is a human gene.

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abraham RT (2005). "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways". DNA Repair (Amst.). 3 (8–9): 919–25. doi:10.1016/j.dnarep.2004.04.003. PMID 15279777.
• Diaz-Meco MT, Municio MM, Sanchez P; et al. (1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. PMID 8524286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa K, Nagase T, Nakajima D; et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. PMID 9455477.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanchez P, De Carcer G, Sandoval IV; et al. (1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Mol. Cell. Biol. 18 (5): 3069–80. PMID 9566925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carmeliet P, Lampugnani MG, Moons L; et al. (1999). "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis". Cell. 98 (2): 147–57. PMID 10428027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denning G, Jamieson L, Maquat LE; et al. (2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashita A, Ohnishi T, Kashima I; et al. (2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMID 11544179.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eichler EE, Johnson ME, Alkan C; et al. (2002). "Divergent origins and concerted expansion of two segmental duplications on chromosome 16". J. Hered. 92 (6): 462–8. PMID 11948212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiu SY, Serin G, Ohara O, Maquat LE (2003). "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. 9 (1): 77–87. PMID 12554878.CS1 maint: Multiple names: authors list (link)
• Ohnishi T, Yamashita A, Kashima I; et al. (2004). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. PMID 14636577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brumbaugh KM, Otterness DM, Geisen C; et al. (2004). "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells". Mol. Cell. 14 (5): 585–98. doi:10.1016/j.molcel.2004.05.005. PMID 15175154.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashima I, Yamashita A, Izumi N; et al. (2006). "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay". Genes Dev. 20 (3): 355–67. doi:10.1101/gad.1389006. PMID 16452507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880.