Richter's transformation
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Richter's transformation, or Richter's Syndrome (RS) is a rare complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL). With Ricther's, CLL changes into a fast-growing diffuse large B cell lymphoma.[3] It affects perhaps 2% to 8% of CLL patients at some point during their lives.
Symptoms
Symptoms of Richter’s transformation include fever, loss of weight and muscle mass, and enlarged lymph nodes.[4] Richter's can appear suddenly, even in patients who were in remission. The prognosis is generally poor, and aggressive treatment is usually warranted.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
