Ribose 1-dehydrogenase (NADP+)

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In enzymology, a ribose 1-dehydrogenase (NADP+) (EC is an enzyme that catalyzes the chemical reaction

D-ribose + NADP+ + H2O D-ribonate + NADPH + H+

The 3 substrates of this enzyme are D-ribose, NADP+, and H2O, whereas its 3 products are D-ribonate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-ribose:NADP+ 1-oxidoreductase. Other names in common use include D-ribose dehydrogenase (NADP+), NADP+-pentose-dehydrogenase, and ribose 1-dehydrogenase (NADP+).


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  • Scher BM, Horecker BL (1966). "Pentose metabolism in Candida. 3. The triphosphopyridine nucleotide-specific polyol dehydrogenase of Candida utilis". Arch. Biochem. Biophys. 116: 117&ndash, 28. PMID 4381350.
  • Schiwara HW, Domschke W, Domagk GF (1968). "[Sugar dehydrogenases in mammalian liver. I. Differentiation of various sugar dehydrogenases from pig liver by disc electrophoresis and ion exchange chromatography]". Hoppe. Seylers. Z. Physiol. Chem. 349: 1575&ndash, 81. PMID 4393642.

External links

The CAS registry number for this enzyme class is 37250-46-7.

Gene Ontology (GO) codes