Restless legs syndrome laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
As restless leg syndrome may be secondary to iron deficiency or kidney diseases or thyroid diseases, all patients should be screened for iron deficiency, kidney diseases and thyroid diseases.
Laboratory Findings
As restless leg syndrome may be secondary to iron deficiency or kidney diseases or thyroid diseases, all patients should be screened for iron deficiency, kidney diseases and thyroid diseases.
- Iron studies usually done for detecting iron deficiency anemia in patients with restless leg syndrome usually are:[1]
- Serum iron- Decreased in iron deficiency
- Transferrin- Elevated in iron deficiency
- Total iron binding capacity (TIBC)- Elevated in iron deficiency
- Transferrin saturation- derived by dividing the serum iron by the TIBC. Decreased in iron deficiency
- Ferritin- Indicator of body iron stores and is low in iron deficiency. However, ferritin also acts as an acute phase reactant and can be unreliable in inflammatory illness
- kidney function tests which usually done for detecting kidney diseases in patients with restless leg syndrome usually are:[2]
- thyroid function tests which usually done for detecting kidney diseases in patients with restless leg syndrome usually are:[3]
References
- ↑ Johnson-Wimbley TD, Graham DY (2011). "Diagnosis and management of iron deficiency anemia in the 21st century". Therap Adv Gastroenterol. 4 (3): 177–84. doi:10.1177/1756283X11398736. PMC 3105608. PMID 21694802.
- ↑ Gade K, Blaschke S, Rodenbeck A, Becker A, Anderson-Schmidt H, Cohrs S (2013). "Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine and parathyroid hormone". Kidney Blood Press Res. 37 (4–5): 458–63. doi:10.1159/000355727. PMID 24247595.
- ↑ Pereira JC, Pradella-Hallinan M, Lins Pessoa Hd (2010). "Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis". Clinics (Sao Paulo). 65 (5): 548–54. doi:10.1590/S1807-59322010000500013. PMC 2882550. PMID 20535374.