Renal artery stenosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In 1930s, Harry Goldblatt established the animal model of renal artery stenosis and observed the alterations in arterial pressure by manipulating renal blood flow in dogs.
Historical Perspective
The regulation of arterial blood pressure by renal perfusion was first recognized in the 1930s by Harry Goldblatt. He demonstrated that partial constriction of the major renal arteries of dogs led to an increase in the blood pressure, and there was a prompt return of pressure following the release of clamps.[1] He claimed that ischemia induces renal secretion of a substance that triggers hypertension.