Retinol dehydrogenase 8 is an enzyme that in humans is encoded by the RDH8gene.[1][2][3]
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001). This is a rate-limiting step in the visual cycle (Saari et al., 1998).[supplied by OMIM][3]
References
↑Rattner A, Smallwood PM, Nathans J (May 2000). "Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol". J Biol Chem. 275 (15): 11034–11043. doi:10.1074/jbc.275.15.11034. PMID10753906.
Luo W, Marsh-Armstrong N, Rattner A, Nathans J (2004). "An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase". J. Neurosci. 24 (11): 2623–2632. doi:10.1523/JNEUROSCI.5302-03.2004. PMID15028754.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID14702039.
Saari JC, Garwin GG, Van Hooser JP, Palczewski K (1998). "Reduction of all-trans-retinal limits regeneration of visual pigment in mice". Vision Res. 38 (10): 1325–1333. doi:10.1016/S0042-6989(97)00198-3. PMID9667000.
