Pyridoxine 5'-phosphate synthase
- 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate pyridoxine 5'-phosphate + phosphate + 2 H2O
This enzyme belongs to the family of transferases, specifically those transferring nitrogenous groups transferring other nitrogenous groups. The systematic name of this enzyme class is 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing). Other names in common use include pyridoxine 5-phosphate phospho lyase, PNP synthase, and PdxJ. This enzyme participates in vitamin b6 metabolism.
- IUBMB entry for 184.108.40.206
- BRENDA references for 220.127.116.11 (Recommended.)
- PubMed references for 18.104.22.168
- PubMed Central references for 22.214.171.124
- Google Scholar references for 126.96.36.199
- Garrido-Franco M (2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond". Biochim. Biophys. Acta. 1647: 92&ndash, 7. PMID 12686115.
- Garrido-Franco M, Laber B, Huber R, Clausen T (2002). "Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis". J. Mol. Biol. 321: 601&ndash, 12. PMID 12206776.
- Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS (1999). "Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein". FEBS. Lett. 449: 45&ndash, 8. PMID 10225425.
- Franco MG, Laber B, Huber R, Clausen T (2001). "Structural basis for the function of pyridoxine 5'-phosphate synthase". Structure. 9: 245&ndash, 53. PMID 11286891.
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