Proprotein convertase subtilisin/kexin type 1 inhibitor

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Proprotein convertase subtilisin/kexin type 1 inhibitor is a protein that in humans is encoded by the PCSK1N gene.

Function

The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity.

Further reading

• Fortenberry Y, Hwang JR, Apletalina EV, Lindberg I (2002). "Functional characterization of ProSAAS: similarities and differences with 7B2". J. Biol. Chem. 277 (7): 5175–86. doi:10.1074/jbc.M104531200. PMID 11719503.
• Wada M, Ren CH, Koyama S, Arawaka S, Kawakatsu S, Kimura H, Nagasawa H, Kawanami T, Kurita K, Daimon M, Hirano A, Kato T (2004). "A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam". Neurosci. Lett. 356 (1): 49–52. PMID 14746899.
• Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I (2009). "Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences". Endocrinology. 150 (3): 1393–9. doi:10.1210/en.2008-1301. PMC 2654743. PMID 18948394.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.