Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us  to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
A polymerase (EC 18.104.22.168/7/19/48/49) is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processes of replication and transcription. In association with a cluster of other enzymes and proteins, they take nucleotides from solution, and catalyse the synthesis of a polynucleotide sequence against a nucleotide template strand using base-pairing interactions.
It is an accident of history that the enzymes responsible for the catalytic production of other biopolymers are not also referred to as polymerases.
One particular polymerase, from the thermophilic bacterium, Thermus aquaticus (Taq) (PDB 1BGX, EC 22.214.171.124) is of vital commercial importance due to its use in the polymerase chain reaction, a widely-used technique of molecular biology.
Other well-known polymerases include:
- Terminal Deoxynucleotidyl Transferase (TdT), which lends diversity to antibody heavy chains
- Reverse Transcriptase, an enzyme used by RNA retroviruses like HIV, which is used to create a complementary strand to the preexisting strand of viral RNA before it can be integrated into the DNA of the host cell. It is also a major target for antiviral drugs.
- DNA polymerase