Pioglitazone drug interactions
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
List of drug interactions
Oral Contraceptives
Glipizide
Digoxin
Warfarin
Metformin
Theophylline
Atorvastatin Calcium
Ketoconazole
Oral Contraceptives
Administration of another thiazolidinedione with an oral contraceptive
containing ethinyl estradiol and norethindrone reduced the plasma concentrations of
both hormones by approximately 30%, which could result in loss of contraception. The
pharmacokinetics of coadministration of Pioglitazone and oral contraceptives have not been
evaluated in patients receiving Pioglitazone and an oral contraceptive. Therefore, additional
caution regarding contraception should be exercised in patients receiving Pioglitazone and
an oral contraceptive. Return to top
Glipizide
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) and
glipizide (5.0 mg once daily) for seven days did not alter the steady-state pharmacokinetics
of glipizide. Return to top
Digoxin
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) with digoxin
(0.25 mg once daily) for seven days did not alter the steady-state pharmacokinetics
of digoxin. Return to top
Warfarin
In healthy volunteers, coadministration of Pioglitazone (45 mg once daily) for
seven days with warfarin did not alter the steady-state pharmacokinetics of warfarin. In
addition, Pioglitazone has no clinically significant effect on prothrombin time when administered
to patients receiving chronic warfarin therapy. Return to top
Metformin
In healthy volunteers, coadministration of metformin (1000 mg) and Pioglitazone
(45 mg) after seven days of Pioglitazone (45 mg once daily) did not alter the pharmacokinetics
of the single dose of metformin. Return to top
Theophylline
Coadministration of Pioglitazone for 7 days with theophylline 400 mg administered
twice daily resulted in no changes in the pharmacokinetics of either drug. Return to top
Atorvastatin Calcium
Coadministration of Pioglitazone for 7 days with atorvastatin 80 mg
once daily resulted in no clinically relevant effect upon atorvastatin pharmacokinetics.
Coadministration of atorvastatin with Pioglitazone had no clinically relevant effect on pioglitazone
pharmacokinetics. Return to top
Ketoconazole
Coadministration of Pioglitazone for 7 days with ketoconazole 200 mg administered
twice daily resulted in no clinically relevant effect on pioglitazone pharmacokinetics. Return to top
The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
