Phthalate 4,5-cis-dihydrodiol dehydrogenase

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In enzymology, a phthalate 4,5-cis-dihydrodiol dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ 4,5-dihydroxyphthalate + NADH + H+

Thus, the two substrates of this enzyme are cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate and NAD+, whereas its 3 products are 4,5-dihydroxyphthalate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.


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  • Batie CJ, LaHaie E, Ballou DP (1987). "Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia". J. Biol. Chem. 262: 1510&ndash, 8. PMID 3805038.

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Gene Ontology (GO) codes