Phosphoribosyl pyrophosphate

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Phosphoribosyl pyrophosphate
Identifiers
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MeSH Phosphoribosyl+pyrophosphate
Properties
C5H13O14P3
Molar mass 390.07 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.

It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.

It plays a role in transferring phosphate groups in several reactions:

Enzyme Reactant Product
adenine phosphoribosyltransferase adenine AMP
hypoxanthine-guanine phosphoribosyltransferase guanine GMP
hypoxanthine-guanine phosphoribosyltransferase hypoxanthine IMP
orotate phosphoribosyltransferase orotate OMP
uracil phosphoribosyltransferase uracil UMP

In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.

See also


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