Phosphatidylinositol (3,5)-bisphosphate

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Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5)-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P2) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)P2 in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking.

PtdIns(3,5)P2 is dephophosphorylated by members of the myotubularin lipid phosphatase family on the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5P).

The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)P2, including the PH domain in centaurin-β2, the PX domain of SNX1, and a novel domain in Atg18p.


  • Michell RH, Heath VL, Lemmon MA, Dove SK. (2006) Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem Sci. 31(1):52-63. [1]

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