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In enzymology, a phosphatidylinositol-3-phosphatase (EC is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O 1-phosphatidyl-1D-myo-inositol + phosphate

Thus, the two substrates of this enzyme are 1-phosphatidyl-1D-myo-inositol 3-phosphate and H2O, whereas its two products are 1-phosphatidyl-1D-myo-inositol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase. Other names in common use include inositol-1,3-bisphosphate 3-phosphatase, inositol 1,3-bisphosphate phosphatase, inositol-polyphosphate 3-phosphatase, D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase, and phosphatidyl-3-phosphate 3-phosphohydrolase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LW3 and 1M7R.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Lips DL, Majerus PW (1989). "The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells". J. Biol. Chem. 264: 19911&ndash, 5. PMID 2555336.
  • Caldwell KK, Lips DL, Bansal VS, Majerus PW (1991). "Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate". J. Biol. Chem. 266: 18378&ndash, 86. PMID 1655747.

External links

The CAS registry number for this enzyme class is 124248-47-1.

Gene Ontology (GO) codes