Pheochromocytoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2] Ifrah Fatima, M.B.B.S[3]
Overview
Adrenal pheochromocytoma and its typical clinical presentation was first described by Frankel in 1886. The term pheochromocytoma was coined by Ludwig Pick in 1912. In 1926, Cesar Roux in Switzerland, Charles H. Mayo in the United States, and Isidor Papo in Yugoslavia were the first surgeons to successfully remove pheochromocytomas. An autopsy revealed President Eisenhower had a 1.5-cm pheochromocytoma in the left adrenal gland.
Historical Perspective
Discovery
- Adrenal pheochromocytoma and its typical clinical presentation was first described by Charles Sugrue in 1800.
- Its histological findings were first reported by Felix Fraenkel and Max Schottelius in 1886.
- Manasse in 1893 reported four cases of adrenocortical tumors and one case of an adrenal medulla tumor.
- Extra-adrenal pheochromocytoma was first described by Alezais and Peyron in 1908.
- The term pheochromocytoma was coined by Ludwig Pick in 1912.
- In 1922, the association between paroxysmal hypertension and pheochromocytoma was described by L’Abbe et al.
- In the early 1900s, there were case reports describing genetic implications in the pathogenesis of pheochromocytomas and its association with syndromes like NF1, VHL, and multiple endocrine neoplasia type 2 (MEN2) emerged.
- Later between 1940 and 1960, literature reviews and case series defined the genetic associations. [1]
Landmark Events in the Development of Treatment Strategies
- In 1926, Cesar Roux in Switzerland, Charles H. Mayo in the United States, and Isidor Papo in Yugoslavia were the first surgeons to successfully surgically remove pheochromocytomas. [2] [3]
Famous Cases
The following are a few famous cases of pheochromocytoma:
- President Eisenhower- After his death, an autopsy revealed a 1.5-cm pheochromocytoma in the left adrenal gland. On analysis of his blood pressure through his life, fluctuating systolic and diastolic blood pressure spikes were documented. [4]
References
- ↑ Else T (2015). "15 YEARS OF PARAGANGLIOMA: Pheochromocytoma, paraganglioma and genetic syndromes: a historical perspective". Endocr Relat Cancer. 22 (4): T147–59. doi:10.1530/ERC-15-0221. PMID 26273101.
- ↑ Kantorovich V, Pacak K (2010). "Pheochromocytoma and paraganglioma". Prog Brain Res. 182: 343–73. doi:10.1016/S0079-6123(10)82015-1. PMC 4714594. PMID 20541673.
- ↑ Kudva YC, Sawka AM, Young WF (2003). "Clinical review 164: The laboratory diagnosis of adrenal pheochromocytoma: the Mayo Clinic experience". J Clin Endocrinol Metab. 88 (10): 4533–9. doi:10.1210/jc.2003-030720. PMID 14557417.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID doi.org/10.1016/j.amjcard.2006.12.043 Check
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