Panniculitis

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Panniculitis
ICD-10 M79.3
ICD-9 729.3
DiseasesDB 29081
MeSH D015434

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List of terms related to Panniculitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous fatty and muscle tissue. Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.

Classification

Histological

It can occur in any fatty tissue (cutaneous or visceral) and is often diagnosed on the basis of a deep skin biopsy, and can be further classified by histological characteristics based on the location of the inflammatory cells (within fatty lobules or in the septa which separate them) and on the presence or absence of vasculitis.

There are thus four main histological subtypes:

  1. lobular panniculitis without vasculitis (acute panniculitis, previously termed Weber-Christian disease [2], systemic nodular panniculitis)
  2. lobular panniculitis with vasculitis
  3. septal panniculitis without vasculitis
  4. septal panniculitis with vasculitis

Symptomatic

Panniculitis can also be classified based on the presence or absence of systemic symptoms:

Associated conditions

Lipoatrophy (the loss of subcutaneous tissue) can occur in any of these conditions.

See also

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