Pancreatic disease

(Redirected from Pancreatopathy)
Jump to navigation Jump to search
Pancreatic disease
ICD-10 K85-K86, Q45.0-Q45.3
ICD-9 577, 751.7
MeSH D010182

WikiDoc Resources for Pancreatic disease

Articles

Most recent articles on Pancreatic disease

Most cited articles on Pancreatic disease

Review articles on Pancreatic disease

Articles on Pancreatic disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Pancreatic disease

Images of Pancreatic disease

Photos of Pancreatic disease

Podcasts & MP3s on Pancreatic disease

Videos on Pancreatic disease

Evidence Based Medicine

Cochrane Collaboration on Pancreatic disease

Bandolier on Pancreatic disease

TRIP on Pancreatic disease

Clinical Trials

Ongoing Trials on Pancreatic disease at Clinical Trials.gov

Trial results on Pancreatic disease

Clinical Trials on Pancreatic disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Pancreatic disease

NICE Guidance on Pancreatic disease

NHS PRODIGY Guidance

FDA on Pancreatic disease

CDC on Pancreatic disease

Books

Books on Pancreatic disease

News

Pancreatic disease in the news

Be alerted to news on Pancreatic disease

News trends on Pancreatic disease

Commentary

Blogs on Pancreatic disease

Definitions

Definitions of Pancreatic disease

Patient Resources / Community

Patient resources on Pancreatic disease

Discussion groups on Pancreatic disease

Patient Handouts on Pancreatic disease

Directions to Hospitals Treating Pancreatic disease

Risk calculators and risk factors for Pancreatic disease

Healthcare Provider Resources

Symptoms of Pancreatic disease

Causes & Risk Factors for Pancreatic disease

Diagnostic studies for Pancreatic disease

Treatment of Pancreatic disease

Continuing Medical Education (CME)

CME Programs on Pancreatic disease

International

Pancreatic disease en Espanol

Pancreatic disease en Francais

Business

Pancreatic disease in the Marketplace

Patents on Pancreatic disease

Experimental / Informatics

List of terms related to Pancreatic disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Pancreatic diseases include:

Pancreatitis

Pancreatitis is inflammation of the pancreas. There are two forms of pancreatitis, which are different in causes and symptoms, and require different treatment:

Diabetes mellitus

The pancreas is central in the pathophysiology of both major types of diabetes mellitus. In type 1 diabetes mellitus, there is direct damage to the endocrine pancreas that results in insufficient insulin synthesis and secretion. Type 2 diabetes mellitus, which begins with insulin resistance, is characterized by the ultimate failure of pancreatic β cells to match insulin production with insulin demand.

Exocrine pancreatic insufficiency

Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. EPI is found in humans afflicted with cystic fibrosis and Shwachman-Diamond Syndrome. It is caused by a progressive loss of the pancreatic cells that make digestive enzymes. Chronic pancreatitis is the most common cause of EPI in humans. Loss of digestive enzymes leads to maldigestion and malabsorption of nutrients.

Cystic fibrosis

Cystic fibrosis, also known as mucoviscidosis, is a hereditary disease that affects the entire body, causing progressive disability and early death. There is no cure for cystic fibrosis, and most affected individuals die young from lung failure. Cystic fibrosis is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The product of this gene helps create sweat, digestive juices, and mucus. Although most people without CF have two working copies of the CFTR gene, only one is needed to prevent cystic fibrosis. Cystic fibrosis develops when neither gene works normally. Therefore, it is considered an autosomal recessive disease. The name cystic fibrosis refers to the characteristic 'fibrosis' (tissue scarring) and cyst formation within the pancreas. Cystic fibrosis causes irreversible damage to the pancreas, which often results in painful inflammation. (pancreatitis).

Pseudocysts

A pancreatic pseudocyst is a circumscribed collection of fluid rich in amylase and other pancreatic enzymes, blood and necrotic tissue, typically located in the lesser sac.

Congenital malformations

Pancreas divisum

Pancreas divisum is a malformation in which the pancreas fails to fuse together. It is a rare condition that affects only 6% of the world's population and of these few only 1% ever have symptoms that require surgery.

Annular pancreas

Annular pancreas is characterized by a pancreas that encircles the duodenum. It results from an embryological malformation in which the early pancreatic buds undergo inappropriate rotation and fusion, which can lead to small bowel obstruction.

Neoplasms

See pancreatic cancer.

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a collection of findings in individuals with gastrinoma, a tumor of the gastrin-producing cells of the pancreas. Unbridled gastrin secretion results in elevated levels of the hormone, and increased hydrochloric acid secretion from parietal cells of the stomach. It can lead to ulceration and scarring of the stomach and intestinal mucosa.

Hemosuccus pancreaticus

Hemosuccus pancreaticus, also known as pseudohematobilia or Wirsungorrhage, is a rare cause of hemorrhage in the gastrointestinal tract. It is caused by a bleeding source in the pancreas, pancreatic duct, or structures adjacent to the pancreas, such as the splenic artery, that bleed into the pancreatic duct. Patients with hemosuccus may develop symptoms of gastrointestinal hemorrhage, such as blood in the stools, maroon stools, or melena. They may also develop abdominal pain. Hemosuccus pancreaticus is associated with pancreatitis, pancreatic cancer and aneurysms of the splenic artery. Angiography may be used to treat hemosuccus pancreaticus, where the celiac axis is injected to determine the blood vessel that is bleeding, because embolization of the end vessel may terminate the hemorrhage. Alternatively, a distal pancreatectomy may be required to stop the hemorrhage.

See also

Template:Gastroenterology Template:Congenital malformations and deformations of digestive system


Template:WH Template:WS