PLA2G1B

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene.

Function

Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals as well as fish. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986) .

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Sapirstein A, Bonventre JV (2000). "Phospholipases A2 in ischemic and toxic brain injury". Neurochem. Res. 25 (5): 745–53. doi:10.1023/A:1007583708713. PMID 10905638.
• Svensson CI, Yaksh TL (2002). "The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing". Annu. Rev. Pharmacol. Toxicol. 42: 553–83. doi:10.1146/annurev.pharmtox.42.092401.143905. PMID 11807183.
• Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. doi:10.1073/pnas.88.12.5418. PMC 51884. PMID 2052621.
• Verheij HM, Westerman J, Sternby B, De Haas GH (1983). "The complete primary structure of phospholipase A2 from human pancreas". Biochim. Biophys. Acta. 747 (1–2): 93–9. doi:10.1016/0167-4838(83)90126-7. PMID 6349696.
• Sternby B, Akerström B (1984). "Immunoreactive pancreatic colipase, lipase and phospholipase A2 in human plasma and urine from healthy individuals". Biochim. Biophys. Acta. 789 (2): 164–9. doi:10.1016/0167-4838(84)90201-2. PMID 6477929.
• Grataroli R, Dijkman R, Dutilh CE, et al. (1982). "Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region". Eur. J. Biochem. 122 (1): 111–7. doi:10.1111/j.1432-1033.1982.tb05855.x. PMID 7060561.
• Rönkkö S (1995). "Immunohistochemical localization of phospholipase A2 in human and bovine male reproductive organs". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 110 (3): 503–9. doi:10.1016/0305-0491(94)00190-6. PMID 7584826.
• Lilja I, Smedh K, Olaison G, et al. (1995). "Phospholipase A2 gene expression and activity in histologically normal ileal mucosa and in Crohn's ileitis". Gut. 37 (3): 380–5. doi:10.1136/gut.37.3.380. PMC 1382819. PMID 7590434.
• Ancian P, Lambeau G, Mattéi MG, Lazdunski M (1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". J. Biol. Chem. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
• Chen J, Engle SJ, Seilhamer JJ, Tischfield JA (1994). "Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2". J. Biol. Chem. 269 (4): 2365–8. PMID 8300559.
• Gispert S, Twells R, Orozco G, et al. (1993). "Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23-24.1". Nat. Genet. 4 (3): 295–9. doi:10.1038/ng0793-295. PMID 8358438.
• Cupillard L, Koumanov K, Mattéi MG, et al. (1997). "Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2". J. Biol. Chem. 272 (25): 15745–52. doi:10.1074/jbc.272.25.15745. PMID 9188469.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes". Arterioscler. Thromb. Vasc. Biol. 18 (12): 1934–41. doi:10.1161/01.ATV.18.12.1934. PMID 9848887.