PEPA (drug)

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PEPA (drug)
Clinical data
Legal status
Legal status
  • Investigational New Medicine
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass402.436 g/mol
3D model (JSmol)

PEPA is an ampakine drug which acts as an allosteric potentiator of AMPA receptor desensitisation,[1][2] which is up to 100x more potent than aniracetam in vitro.[3] It produces memory-enhancing effects in rats when administered intravenously.[4]


  1. Sekiguchi M, Takeo J, Harada T, Morimoto T, Kudo Y, Yamashita S, Kohsaka S, Wada K. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. British Journal of Pharmacology. 1998 Apr;123(7):1294-303. PMID 9579722
  2. Sekiguchi M, Nishikawa K, Aoki S, Wada K. A desensitization-selective potentiator of AMPA-type glutamate receptors. British Journal of Pharmacology. 2002 Aug;136(7):1033-41. PMID 12145103
  3. Sekiguchi M, Fleck MW, Mayer ML, Takeo J, Chiba Y, Yamashita S, Wada K. A novel allosteric potentiator of AMPA receptors: 4--2-(phenylsulfonylamino)ethylthio--2,6-difluoro-phenoxyaceta mide. Journal of Neuroscience. 1997 Aug 1;17(15):5760-71. PMID 9221774
  4. Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, Kamichi S, Kimura I, Wada K. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport. 2001 Sep 17;12(13):2947-50. PMID 11588608