PAH clearance

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Overview

Para aminohippurate clearance or PAH clearance is a method used in renal physiology to measure renal plasma flow, which, in turn, is a measure of renal function.

The concentration of para aminohippurate (PAH) is measured in one arterial blood sample (PPAH) and one urine sample(UPAH). The urine flow (V) as also measured. Renal perfusion flow is then calculated by:

RPF = \frac{U_{PAH}}{P_{PAH}} V

What in fact is calculated is the effective renal plasma flow (eRPF). However, since the renal extraction ratio of PAH almost equals 1, then eRPF almost equals RPF.

Precision

The renal extraction ratio of PAH is a normal individual is approximately 0.92[1], and thus not exactly 1.0. Thus, this method usually underestimates RPF by approximately 10%. This margin of error is generally acceptable considering the ease with which eRPF is measured.

References

  1. Reubi FC. Glomberular Filtration Rate, Renal Blood Flow and Blood Viscosity during and after Diabetic Coma. Circ. Res. 1953;1;410-413. Available at: http://circres.ahajournals.org/cgi/reprint/1/5/410.pdf. Accessed on: May 2, 2007.

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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