Occupational lung disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
If left untreated, patients with occupational lung disease may progress to develop pleural effusion, interstitial lung fibrosis, and lung cancer. Common complications of of occupational lung disease include interstitial pulmonary fibrosis, progressive massive fibrosis, mesothelioma, and premature death. Depending on the extent of the disease progression at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of occupational lung disease usually develop on average in the third decade of life, and start with symptoms such as shortness of breath, fatigue, and cough.[1]
- The symptoms of occupational lung disease typically develop 30 years after exposure to an inhalant.
- If left untreated, 30% of patients with occupational lung disease may progress to develop pleural effusion, interstitial lung fibrosis, and lung cancer.
Complications
Prognosis
- Depending on the extent of the disease progression at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.[4]
- The presence of fibrosis is associated with a particularly poor prognosis among patients with occupational lung disease.
References
- ↑ Turcotte SE, Chee A, Walsh R, Grant FC, Liss GM, Boag A, Forkert L, Munt PW, Lougheed MD (2013). "Flock worker's lung disease: natural history of cases and exposed workers in Kingston, Ontario". Chest. 143 (6): 1642–1648. doi:10.1378/chest.12-0920. PMID 23699830.
- ↑ Dumas O, Despreaux T, Perros F, Lau E, Andujar P, Humbert M, Montani D, Descatha A (2018). "Respiratory effects of trichloroethylene". Respir Med. 134: 47–53. doi:10.1016/j.rmed.2017.11.021. PMID 29413507.
- ↑ Baur X (2018). "Asbestos-Related Disorders in Germany: Background, Politics, Incidence, Diagnostics and Compensation". Int J Environ Res Public Health. 15 (1). doi:10.3390/ijerph15010143. PMC 5800242. PMID 29337930.
- ↑ Gouvinhas C, De Mello RA, Oliveira D, Castro-Lopes JM, Castelo-Branco P, Dos Santos RS, Hespanhol V, Pozza DH (2018). "Lung cancer: a brief review of epidemiology and screening". Future Oncol. doi:10.2217/fon-2017-0486. PMID 29417838.