O-succinylbenzoate-CoA ligase

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In enzymology, an o-succinylbenzoate-CoA ligase (EC 6.2.1.26) is an enzyme that catalyzes the chemical reaction

ATP + o-succinylbenzoate + CoA AMP + diphosphate + o-succinylbenzoyl-CoA

The 3 substrates of this enzyme are ATP, o-succinylbenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and o-succinylbenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 2-succinylbenzoate:CoA ligase (AMP-forming). Other names in common use include 2-succinylbenzoyl-coenzyme A synthetase, and 2-succinylbenzoate:CoA ligase (AMP-forming). This enzyme participates in ubiquinone biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OKT and 2OLA.

References

  • IUBMB entry for 6.2.1.26
  • BRENDA references for 6.2.1.26 (Recommended.)
  • PubMed references for 6.2.1.26
  • PubMed Central references for 6.2.1.26
  • Google Scholar references for 6.2.1.26
  • Heide L, Arendt S, Leistner E (1982). "Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis". J. Biol. Chem. 257: 7396&ndash, 400. PMID 7045104.
  • Kolkmann R, Leistner E (1987). "4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis". Z. Naturforsch. [C]. 42: 1207&ndash, 14. PMID 2966501.
  • Meganathan R, Bentley R (1979). "Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes". J. Bacteriol. 140: 92&ndash, 8. PMID 500558.

External links

The CAS registry number for this enzyme class is 72506-70-8.

Gene Ontology (GO) codes

Template:Ligase-stub



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