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In enzymology, a N-sulfoglucosamine-3-sulfatase (EC is an enzyme that catalyzes the chemical reaction of cleaving off the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is N-sulfo-3-sulfoglucosamine 3-sulfohydrolase. This enzyme is also called chondroitinsulfatase. This enzyme participates in the degradtaion of glycan structures.


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  • Bruce JS, McLean MW, Long WF, Williamson FB (1985). "Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate". Eur. J. Biochem. 148: 359&ndash, 65. PMID 3987694.
  • Leder IG (1980). "A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate". Biochem. Biophys. Res. Commun. 94: 1183&ndash, 9. PMID 7396957.

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