N-hydroxyarylamine O-acetyltransferase

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In enzymology, a N-hydroxyarylamine O-acetyltransferase (EC 2.3.1.118) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an N-hydroxyarylamine CoA + an N-acetoxyarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and N-hydroxyarylamine, whereas its two products are CoA and N-acetoxyarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-hydroxyarylamine O-acetyltransferase. Other names in common use include arylhydroxamate N,O-acetyltransferase, arylamine N-acetyltransferase, and N-hydroxy-2-aminofluorene-O-acetyltransferase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1E2T.

References

  • IUBMB entry for 2.3.1.118
  • BRENDA references for 2.3.1.118 (Recommended.)
  • PubMed references for 2.3.1.118
  • PubMed Central references for 2.3.1.118
  • Google Scholar references for 2.3.1.118
  • Saito K, Shinohara A, Kamataki T, Kato R (Tokyo). "N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase". J. Biochem.: 1689&ndash, 97. PMID 3745141. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 100984-92-7.

Gene Ontology (GO) codes



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