Myeloperoxidase deficiency

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Myeloperoxidase deficiency
Hypochlorous-acid-3D-vdW.png
Hypochlorous acid is normally produced by myeloperoxidase
OMIM 254600
DiseasesDB 8662
eMedicine ped/1530 

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Overview

Myeloperoxidase deficiency is a common genetic disorder featuring deficiency, either in quantity or function, of myeloperoxidase, an enzyme found in certain phagocytic immune cells, especially polymorphonuclear leukocytes.

It can appear similar to chronic granulomatous disease on some screening tests.[1]

Presentation

Although MPO deficiency classically presents with immune deficiency (especially candida albicans infections), the majority of individuals with MPO deficiency show no signs of immunodeficiency.

The lack of severe symptoms suggest that role of myeloperoxidase in the immune response must be redundant to other mechanisms of intracellular killing of phagocytosed bacteria.[2]

References

  1. Mauch L, Lun A, O'Gorman MR; et al. (2007). "Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD". Clin. Chem. 53 (5): 890–6. PMID 17384005. doi:10.1373/clinchem.2006.083444. 
  2. Levinson, Warren. "Medical Microbiology & Immunology, 8th ed." Lange:2004.

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| group5 = Clinical Trials Involving Myeloperoxidase deficiency | list5 = Ongoing Trials on Myeloperoxidase deficiency at Clinical Trials.govTrial results on Myeloperoxidase deficiencyClinical Trials on Myeloperoxidase deficiency at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Myeloperoxidase deficiency | list6 = US National Guidelines Clearinghouse on Myeloperoxidase deficiencyNICE Guidance on Myeloperoxidase deficiencyNHS PRODIGY GuidanceFDA on Myeloperoxidase deficiencyCDC on Myeloperoxidase deficiency


| group7 = Textbook Information on Myeloperoxidase deficiency | list7 = Books and Textbook Information on Myeloperoxidase deficiency


| group8 = Pharmacology Resources on Myeloperoxidase deficiency | list8 = AND (Dose)}} Dosing of Myeloperoxidase deficiencyAND (drug interactions)}} Drug interactions with Myeloperoxidase deficiencyAND (side effects)}} Side effects of Myeloperoxidase deficiencyAND (Allergy)}} Allergic reactions to Myeloperoxidase deficiencyAND (overdose)}} Overdose information on Myeloperoxidase deficiencyAND (carcinogenicity)}} Carcinogenicity information on Myeloperoxidase deficiencyAND (pregnancy)}} Myeloperoxidase deficiency in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Myeloperoxidase deficiency


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Myeloperoxidase deficiency | list9 = AND (pharmacogenomics)}} Genetics of Myeloperoxidase deficiencyAND (pharmacogenomics)}} Pharmacogenomics of Myeloperoxidase deficiencyAND (proteomics)}} Proteomics of Myeloperoxidase deficiency


| group10 = Newstories on Myeloperoxidase deficiency | list10 = Myeloperoxidase deficiency in the newsBe alerted to news on Myeloperoxidase deficiencyNews trends on Myeloperoxidase deficiency


| group11 = Commentary on Myeloperoxidase deficiency | list11 = Blogs on Myeloperoxidase deficiency

| group12 = Patient Resources on Myeloperoxidase deficiency | list12 = Patient resources on Myeloperoxidase deficiencyDiscussion groups on Myeloperoxidase deficiencyPatient Handouts on Myeloperoxidase deficiencyDirections to Hospitals Treating Myeloperoxidase deficiencyRisk calculators and risk factors for Myeloperoxidase deficiency


| group13 = Healthcare Provider Resources on Myeloperoxidase deficiency | list13 = Symptoms of Myeloperoxidase deficiencyCauses & Risk Factors for Myeloperoxidase deficiencyDiagnostic studies for Myeloperoxidase deficiencyTreatment of Myeloperoxidase deficiency

| group14 = Continuing Medical Education (CME) Programs on Myeloperoxidase deficiency | list14 = CME Programs on Myeloperoxidase deficiency

| group15 = International Resources on Myeloperoxidase deficiency | list15 = Myeloperoxidase deficiency en EspanolMyeloperoxidase deficiency en Francais

| group16 = Business Resources on Myeloperoxidase deficiency | list16 = Myeloperoxidase deficiency in the MarketplacePatents on Myeloperoxidase deficiency

| group17 = Informatics Resources on Myeloperoxidase deficiency | list17 = List of terms related to Myeloperoxidase deficiency


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