Mitochondrial fission factor

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.[1]

Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission.[2] Mff also regulates peroxisome morphology.[3]

References

  1. ↑ "Entrez Gene: mitochondrial fission factor".
  2. ↑ Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K (Dec 2010). "Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells". The Journal of Cell Biology. 191 (6): 1141–58. doi:10.1083/jcb.201007152. PMC 3002033. PMID 21149567.
  3. ↑ Gandre-Babbe S, van der Bliek AM (Jun 2008). "The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells". Molecular Biology of the Cell. 19 (6): 2402–12. doi:10.1091/mbc.E07-12-1287. PMC 2397315. PMID 18353969.

Further reading

  • Igci YZ, Arslan A, Akarsu E, Erkilic S, Igci M, Oztuzcu S, Cengiz B, Gogebakan B, Cakmak EA, Demiryurek AT (Jun 2011). "Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma". Endocrine Pathology. 22 (2): 86–96. doi:10.1007/s12022-011-9157-8. PMID 21509594.
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