Methylglyoxal reductase (NADH-dependent)

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In enzymology, a methylglyoxal reductase (NADH-dependent) (EC 1.1.1.78) is an enzyme that catalyzes the chemical reaction

(R)-lactaldehyde + NAD+ methylglyoxal + NADH + H+

Thus, the two substrates of this enzyme are (R)-lactaldehyde and NAD+, whereas its 3 products are methylglyoxal, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include methylglyoxal reductase, and D-lactaldehyde dehydrogenase. This enzyme participates in pyruvate metabolism.

References

  • IUBMB entry for 1.1.1.78
  • BRENDA references for 1.1.1.78 (Recommended.)
  • PubMed references for 1.1.1.78
  • PubMed Central references for 1.1.1.78
  • Google Scholar references for 1.1.1.78
  • TING SM, MILLER ON, SELLINGER OZ (1965). "THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER". Biochim. Biophys. Acta. 97: 407&ndash, 15. PMID 14323585.

External links

The CAS registry number for this enzyme class is 37250-16-1.

Gene Ontology (GO) codes


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