Malate dehydrogenase (oxaloacetate-decarboxylating)

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In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) (EC is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD+ Failed to parse (MathML with SVG or PNG fallback (recommended for modern browsers and accessibility tools): Invalid response ("Math extension cannot connect to Restbase.") from server "":): \rightleftharpoons pyruvate + CO2 + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD+, whereas its 3 products are pyruvate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, NAD+-malic enzyme, and NAD+-linked malic enzyme. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1GZ3, 1LLQ, 1O0S, 1PJL, 1WW8, and 2DVM.


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  • Kaufman S, Korkes S and del Campillo A (1951). "Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V Further studies of the "malic" enzyme of Lactobacillus arabinosus". J. Biol. Chem. 192: 301&ndash, 312.

External links

The CAS registry number for this enzyme class is 9080-52-8.

Gene Ontology (GO) codes