LGALS7

Lectin, galactoside-binding, soluble, 7 (galectin 7)
File:PBB Protein LGALS7 image.jpg PDB rendering based on 1bkz.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bkz​, 2gal​, 3gal​, 4gal​, 5gal​
Identifiers
Symbols	LGALS7 ; GAL7; PIG1; TP53I1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37609
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lectin, galactoside-binding, soluble, 7 (galectin 7), also known as LGALS7, is a human gene.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell-cell and/or cell-matrix interactions necessary for normal growth control.

Further reading

• Madsen P, Rasmussen HH, Flint T; et al. (1995). "Cloning, expression, and chromosome mapping of human galectin-7". J. Biol. Chem. 270 (11): 5823–9. PMID 7534301.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Polyak K, Xia Y, Zweier JL; et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magnaldo T, Fowlis D, Darmon M (1998). "Galectin-7, a marker of all types of stratified epithelia". Differentiation. 63 (3): 159–68. PMID 9697310.CS1 maint: Multiple names: authors list (link)
• Leonidas DD, Vatzaki EH, Vorum H; et al. (1998). "Structural basis for the recognition of carbohydrates by human galectin-7". Biochemistry. 37 (40): 13930–40. doi:10.1021/bi981056x. PMID 9760227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernerd F, Sarasin A, Magnaldo T (1999). "Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11329–34. PMID 10500176.CS1 maint: Multiple names: authors list (link)
• Kuwabara I, Kuwabara Y, Yang RY; et al. (2002). "Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release". J. Biol. Chem. 277 (5): 3487–97. doi:10.1074/jbc.M109360200. PMID 11706006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cao Z, Said N, Wu HK; et al. (2003). "Galectin-7 as a potential mediator of corneal epithelial cell migration". Arch. Ophthalmol. 121 (1): 82–6. PMID 12523890.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kopitz J, André S, von Reitzenstein C; et al. (2003). "Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells". Oncogene. 22 (40): 6277–88. doi:10.1038/sj.onc.1206631. PMID 13679866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saussez S, Cucu DR, Decaestecker C; et al. (2006). "Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer". Ann. Surg. Oncol. 13 (7): 999–1009. doi:10.1245/ASO.2006.08.033. PMID 16788763.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)