L-lysine 6-transaminase

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In enzymology, a L-lysine 6-transaminase (EC is an enzyme that catalyzes the chemical reaction

L-lysine + 2-oxoglutarate 2-aminoadipate 6-semialdehyde + L-glutamate

Thus, the two substrates of this enzyme are L-lysine and 2-oxoglutarate, whereas its two products are 2-aminoadipate 6-semialdehyde and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-lysine:2-oxoglutarate 6-aminotransferase. Other names in common use include lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine:2-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, and L-lysine-alpha-ketoglutarate 6-aminotransferase. This enzyme participates in lysine biosynthesis. It employs one cofactor, pyridoxal phosphate.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Soda K, Misono H, Yamamoto T (1968). "L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid". Biochemistry. 7: 4102&ndash, 9. PMID 5722275.
  • Soda K, Misono H (1968). "L-Lysine:alpha-ketoglutarate aminotransferase. II. Purification, crystallization, and properties". Biochemistry. 7: 4110&ndash, 9. PMID 5722276.

External links

The CAS registry number for this enzyme class is 9054-68-6.

Gene Ontology (GO) codes