Interstitial nephritis historical perspective

Jump to navigation Jump to search

Interstitial nephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Interstitial nephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Interstitial nephritis historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Interstitial nephritis historical perspective

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Interstitial nephritis historical perspective

CDC on Interstitial nephritis historical perspective

Interstitial nephritis historical perspective in the news

Blogs on Interstitial nephritis historical perspective

Directions to Hospitals Treating Interstitial nephritis

Risk calculators and risk factors for Interstitial nephritis historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. ; Associate Editor(s)-in-Chief:Mohsen Basiri M.D.

Overview

In 1938, Councilman was the first to discover the association between systemic infections and the development of TIN; In autopsy kidneys of children dying of diphtheria and scarlet fever.He described the findings as: cellular and fluid exudation in the interstitial tissue of kidneys, before the era of antibiotics.

Historical Perspective

In 1938, Councilman was the first to discover the association between systemic infections and the development of TIN; in autopsy kidneys of children dying of diphtheria and scarlet fever.[1] He described the findings as: cellular and fluid exudation in the interstitial tissue of kidneys, before the era of antibiotics.

With development of renal biopsy led to find of similar characteristic in association with drug-related renal failure, histological examination in acute TIN reveals an infiltrate, which is largely composed of T cells, together with some macrophages and plasma cells. As there is some evidence for cutaneous delayed-type hypersensitivity and positive in vitrolymphocyte stimulation tests in response to suspected drugs, the etiology is presumed to be immune-mediated [2]. This is illustrated by the rapid recrudescence of disease upon inadvertent rechallenge in drug-related ATIN, a clear manifestation of an immunological memory response.[3][4]

References

  1. Councilman WT. Acute interstitial nephritis. J Exp Med 1898; 3: 393
  2. Kelly C, Tomaszewski J, Neilson E. Immunopathogenic mechanisms of tubulointerstitial injury. In: Tisher C, Brenner B, eds, Renal Pathology: With Clinical and Functional Correlations, 2nd Edn., Vol. 1. J. B. Lippincott & Co, Philadelphia, PA, 1994; 699–722
  3. Pusey CD, Saltissi D, Bloodworth L, Rainford DJ, Christie JL. Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Q J Med 1983; 52: 194–211
  4. Sloth K, Thomsen AC. Acute renal insufficiency during treatment with azathioprine. Acta Med Scand 1971; 189: 145–148

Template:WH Template:WS