Inositol triphosphate receptor

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inositol 1,4,5-triphosphate receptor, type 1
Identifiers
SymbolITPR1
Entrez3708
HUGO6180
OMIM147265
RefSeqNM_002222
UniProtQ14643
Other data
LocusChr. 3 p26.1
inositol 1,4,5-triphosphate receptor, type 2
Identifiers
SymbolITPR2
Entrez3709
HUGO6181
OMIM600144
RefSeqNM_002223
UniProtQ14571
Other data
LocusChr. 12 p11.23
inositol 1,4,5-triphosphate receptor, type 3
Identifiers
SymbolITPR3
Entrez3710
HUGO6182
OMIM147267
RefSeqNM_002224
UniProtQ14573
Other data
LocusChr. 6 p21.31

Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).

Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.

Structure

The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

See also

External links



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