Inositol 3-kinase

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In enzymology, an inositol 3-kinase (EC 2.7.1.64) is an enzyme that catalyzes the chemical reaction

ATP + myo-inositol ADP + 1D-myo-inositol 3-phosphate

Thus, the two substrates of this enzyme are ATP and myo-inositol, whereas its two products are ADP and 1D-myo-inositol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:myo-inositol 1-phosphotransferase. Other names in common use include inositol-1-kinase (phosphorylating), myoinositol kinase, and myo-inositol 1-kinase. This enzyme participates in inositol phosphate metabolism.

References

  • IUBMB entry for 2.7.1.64
  • BRENDA references for 2.7.1.64 (Recommended.)
  • PubMed references for 2.7.1.64
  • PubMed Central references for 2.7.1.64
  • Google Scholar references for 2.7.1.64
  • English PD, Dietz M and Albersheim P (1966). "Myoinositol kinase: partial purification and identification of product". Science. 151: 198&ndash, 199.
  • and Loewus FA (1982). "Enantiomeric form of myo-inositol-1-phosphate produced by myo-inositol-1-phosphate synthase and myoinositol kinase in higher-plants". Plant Physiol. 70: 1661&ndash, 1663.
  • Stephens LR, Kay RR, Irvine RF (1990). "A myo-inositol D-3 hydroxykinase activity in Dictyostelium". Biochem. J. 272: 201&ndash, 10. PMID 2176081.

External links

The CAS registry number for this enzyme class is 37278-07-2.

Gene Ontology (GO) codes


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