Inositol-trisphosphate 3-kinase

In enzymology, an inositol-trisphosphate 3-kinase (EC 2.7.1.127) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,4,5-trisphosphate $\rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,4,5-trisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase. Other names in common use include 1D-myo-inositol-trisphosphate 3-kinase, and Ins(1,4,5)P3 3-kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, calcium signaling pathway, and phosphatidylinositol signaling system. This enzyme has at least one effector, Calcium.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1TZD, 2A98, and 2AQX.

References

• IUBMB entry for 2.7.1.127
• BRENDA references for 2.7.1.127 (Recommended.)
• PubMed references for 2.7.1.127
• PubMed Central references for 2.7.1.127
• Google Scholar references for 2.7.1.127
• Hansen CA, Mah S, Williamson JR (1986). "Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver". J. Biol. Chem. 261: 8100&ndash, 3. PMID 3487541.CS1 maint: Multiple names: authors list (link)
• Irvine RF, Letcher AJ, Heslop JP, Berridge MJ (1986). "The inositol tris/tetrakisphosphate pathway — demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues". Nature. 320: 631&ndash, 4. PMID 3010126.CS1 maint: Multiple names: authors list (link)
• Irvine RF, Schell MJ (2001). "Back in the water: the return of the inositol phosphates". Nat. Rev. Mol. Cell. Biol. 2: 327&ndash, 38. PMID 11331907.

External links

The CAS registry number for this enzyme class is 106283-10-7.

• IUBMB entry for 2.7.1.127

• KEGG entry for 2.7.1.127

• BRENDA entry for 2.7.1.127

• NiceZyme view of 2.7.1.127

• EC2PDB: PDB structures for 2.7.1.127

• PRIAM entry for 2.7.1.127

• PUMA2 entry for 2.7.1.127

• IntEnz: Integrated Enzyme entry for 2.7.1.127

• MetaCyc entry for 2.7.1.127

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0008440: inositol trisphosphate 3-kinase

• AMIGO entry for GO code 0008440: inositol trisphosphate 3-kinase