Hypoprothrombinemia
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| Hypoprothrombinemia Classification and external resources | |
| ICD-9 | 286.3, 776.3 |
|---|---|
| eMedicine | ped/1133 |
| MeSH | D007020 |
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Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.
Causes
Hypoprothrombinemia can be the result of a genetic defect or it may be acquired as the result of another disease process, or an adverse effect of medication. For example, 5-10% of patients with Systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome).[1]
Treatment
Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes.[2]
References
- ↑ Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D (1983). "A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome.". Blood 61 (4): 684–92. PMID 6403077.
- ↑ Lechler E (1999). "Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin, factor VII, factor X, protein C protein S, or protein Z.". Thromb Res 95 (4 Suppl 1): S39–50. doi:10.1016/S0049-3848(99)00083-3. PMID 10499908.
Certain conditions originating in the perinatal period (P, 760-779) | |
|---|---|
| Maternal factors and complications | Umbilical cord prolapse - Nuchal cord - Chorioamnionitis |
| Length of gestation and fetal growth | Small for gestational age - Large for gestational age - Premature birth - Postmature birth |
| Birth trauma | Cephalhematoma - Brachial plexus lesion (Erb's palsy, Klumpke paralysis) |
| Respiratory | Intrauterine hypoxia - Infant respiratory distress syndrome - Transient tachypnea of the newborn - Meconium aspiration syndrome - pleural disease (Pneumothorax, Pneumomediastinum) - Wilson-Mikity syndrome - Bronchopulmonary dysplasia |
| Cardiovascular | Pneumopericardium - Persistent fetal circulation |
| Haemorrhagic and haematological/ hematologic disease | Haemorrhagic disease of the newborn - Hemolytic disease of the newborn - Rh disease - Hydrops fetalis - Hyperbilirubinemia (Kernicterus, Neonatal jaundice) |
| Digestive system | Ileus - Necrotizing enterocolitis |
| Integument and temperature regulation | Erythema toxicum |
| Other disorders | Periventricular leukomalacia - Gray baby syndrome - muscle tone (Congenital hypertonia, Congenital hypotonia) - Perinatal infection (Congenital rubella syndrome) - Velamentous cord insertion - Omphalitis |
WikiDoc Research Resources for Hypoprothrombinemia | |
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| Articles on Hypoprothrombinemia | Most recent articles on Hypoprothrombinemia • Most cited articles on Hypoprothrombinemia • Review articles on Hypoprothrombinemia • Articles on Hypoprothrombinemia in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Hypoprothrombinemia | Powerpoint slides on Hypoprothrombinemia • Images of Hypoprothrombinemia • Photos of Hypoprothrombinemia • Podcasts & MP3s on Hypoprothrombinemia • Videos on Hypoprothrombinemia |
| Evidence Based Medicine Regarding Hypoprothrombinemia | Cochrane Collaboration on Hypoprothrombinemia • Bandolier on Hypoprothrombinemia • TRIP on Hypoprothrombinemia |
| Cost Effectiveness of Hypoprothrombinemia | Cost Effectiveness of Hypoprothrombinemia |
| Clinical Trials Involving Hypoprothrombinemia | Ongoing Trials on Hypoprothrombinemia at Clinical Trials.gov • Trial results on Hypoprothrombinemia • Clinical Trials on Hypoprothrombinemia at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Hypoprothrombinemia | US National Guidelines Clearinghouse on Hypoprothrombinemia • NICE Guidance on Hypoprothrombinemia • NHS PRODIGY Guidance • FDA on Hypoprothrombinemia • CDC on Hypoprothrombinemia |
| Textbook Information on Hypoprothrombinemia | Books and Textbook Information on Hypoprothrombinemia |
| Pharmacology Resources on Hypoprothrombinemia | Dosing of Hypoprothrombinemia • Drug interactions with Hypoprothrombinemia • Side effects of Hypoprothrombinemia • Allergic reactions to Hypoprothrombinemia • Overdose information on Hypoprothrombinemia • Carcinogenicity information on Hypoprothrombinemia • Hypoprothrombinemia in pregnancy • Pharmacokinetics of Hypoprothrombinemia • |
| Genetics, Pharmacogenomics, and Proteinomics of Hypoprothrombinemia | Genetics of Hypoprothrombinemia • Pharmacogenomics of Hypoprothrombinemia • Proteomics of Hypoprothrombinemia |
| Newstories on Hypoprothrombinemia | Hypoprothrombinemia in the news • Be alerted to news on Hypoprothrombinemia • News trends on Hypoprothrombinemia |
| Commentary on Hypoprothrombinemia | Blogs on Hypoprothrombinemia |
| Patient Resources on Hypoprothrombinemia | Patient resources on Hypoprothrombinemia • Discussion groups on Hypoprothrombinemia • Patient Handouts on Hypoprothrombinemia • Directions to Hospitals Treating Hypoprothrombinemia • Risk calculators and risk factors for Hypoprothrombinemia |
| Healthcare Provider Resources on Hypoprothrombinemia | Symptoms of Hypoprothrombinemia • Causes & Risk Factors for Hypoprothrombinemia • Diagnostic studies for Hypoprothrombinemia • Treatment of Hypoprothrombinemia |
| Continuing Medical Education (CME) Programs on Hypoprothrombinemia | CME Programs on Hypoprothrombinemia |
| International Resources on Hypoprothrombinemia | Hypoprothrombinemia en Espanol • Hypoprothrombinemia en Francais |
| Business Resources on Hypoprothrombinemia | Hypoprothrombinemia in the Marketplace • Patents on Hypoprothrombinemia |
| Informatics Resources on Hypoprothrombinemia | List of terms related to Hypoprothrombinemia |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
