Hydrogen:quinone oxidoreductase

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In enzymology, a hydrogen:quinone oxidoreductase (EC is an enzyme that catalyzes the chemical reaction

H2 + menaquinone menaquinol

Thus, the two substrates of this enzyme are H2 and menaquinone, whereas its product is menaquinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with a quinone or similar compound as acceptor. The systematic name of this enzyme class is hydrogen:quinone oxidoreductase. Other names in common use include hydrogen-ubiquinone oxidoreductase, hydrogen:menaquinone oxidoreductase, membrane-bound hydrogenase, and quinone-reactive Ni/Fe-hydrogenase.


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  • E, Duchene A, Tripier D, Juvenal K; et al. (1992). "The quinone-reactive Ni/Fe-hydrogenase of Wolinella succinogenes". Eur. J. Biochem. 206: 93&ndash, 102. PMID 1587288.
  • E, Duchene A, Tripier D, Juvenal K; et al. (1993). "The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes". Eur. J. Biochem. 214: 949&ndash, 50. PMID 8319698.
  • Gross R, Simon J, Lancaster CR, Kroger A (1998). "Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2". Mol. Microbiol. 30: 639&ndash, 46. PMID 9822828.
  • Bernhard M, Benelli B, Hochkoeppler A, Zannoni D, Friedrich B (1997). "Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16". Eur. J. Biochem. 248: 179&ndash, 86. PMID 9310376.
  • Ferber DM, Maier RJ (1993). "Hydrogen-ubiquinone oxidoreductase activity by the Bradyrhizobium japonicum membrane-bound hydrogenase". FEMS. Microbiol. Lett. 110: 257&ndash, 64. PMID 8354459.
  • Kodama T (1991). "Methionaquinone is a direct natural electron-acceptor for the membrane-bound hydrogenase in Hydrogenobacter thermophilus strain TK-6". Agric. Biol. Chem. 55: 3011&ndash, 3016.

External links

The CAS registry number for this enzyme class is 147097-29-8.

Gene Ontology (GO) codes