Hereditary pancreatitis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Iqra Qamar M.D.[2]
Overview
In 1642, Johannes Wirsung of Padua first described the pancreatic duct and the concept of the pancreas as a secretory organ. In 1952, Comfort and Steinberg , were the first one to identify a genetic background associated with hereditary pancreatitis and they found hereditary pancreatitis in six family members spanning 3 generations. In 1996, a gene for hereditary chronic pancreatitis was mapped to chromosome 7.
Historical Perspective
Discovery
The historical landmarks in the diagnostic evaluation and management of pancreatitis are as follows:[1] [2]
- In 1642, Johannes Wirsung of Padua first described the pancreatic duct and the concept of the pancreas as a secretory organ.
- In 1737, Giovanni Santorini of Venice identified a second, accessory duct and was credited with primacy in the discovery of the ampulla of Vater.
- In 1887, Rugero Oddi published his observations of the structure and function of the choledochal sphincter in Archives Italiennes de Biologie that laid the basis for understanding its role in pancreatic and biliary disease.
- In the 16th century, Sylvius Franciscus de la Boe Sylvius found that the pancreas discharged a fluid that mixed with the partly digested food and bile in the intestine causing an effervescence ("effervescentia intestinalis") which liquefied food.
- In the 16th century, Regnier de Graaf of Delft devised novel surgical techniques to create pancreatic fistulas (center) to collect this juice for analysis.
- In 1652, Nicholaes Tulp of Amsterdam is credited with the first description of acute pancreatitis.
- In 1761, Giovanni Morgagni described the clinical syndrome of severe upper abdominal pain, vomiting, and collapse (acute pancreatitis). He is also credited with the earliest pathological recognition of cancer of the pancreas.
- In 1652, Nicholaes Tulp was credited with the first description of acute pancreatitis
- In 1842, Karl von Rokitansky, the premier pathologist of Vienna (Wiener Allgemeines Krankenhaus) was the first one to recognize acute hemorrhagic pancreatitis.
- In late 18th century, Reginald Fitz described 3 forms of acute pancreatitis (hemorrhagic, suppurative, and gangrenous) and proposed that fat necrosis was a sequel of severe pancreatitis
- In late 18th century, Nicholas Senn of Chicago, not only addressed the mechanisms of acute pancreatitis but also provided rational insight into the validity of surgical techniques for its treatment.
- In 1952, Comfort and Steinberg , were the first one to identify a genetic background associated with hereditary pancreatitis and they found hereditary pancreatitis in six family members spanning 3 generations.[3]
- In 1996, a gene for hereditary chronic pancreatitis was mapped to chromosome 7.[4][5][6]
References
- ↑ Pannala R, Kidd M, Modlin IM (2009). "Acute pancreatitis: a historical perspective". Pancreas. 38 (4): 355–66. doi:10.1097/MPA.0b013e318199161c. PMID 19390402.
- ↑ Fitz, Reginald H. (1889). "Acute Pancreatitis". The Boston Medical and Surgical Journal. 120 (8): 181–187. doi:10.1056/NEJM188902211200801. ISSN 0096-6762.
- ↑ COMFORT MW, STEINBERG AG (1952). "Pedigree of a family with hereditary chronic relapsing pancreatitis". Gastroenterology. 21 (1): 54–63. PMID 14926813.
- ↑ Whitcomb DC, Preston RA, Aston CE, Sossenheimer MJ, Barua PS, Zhang Y, Wong-Chong A, White GJ, Wood PG, Gates LK, Ulrich C, Martin SP, Post JC, Ehrlich GD (1996). "A gene for hereditary pancreatitis maps to chromosome 7q35". Gastroenterology. 110 (6): 1975–80. PMID 8964426.
- ↑ Le Bodic L, Bignon JD, Raguénès O, Mercier B, Georgelin T, Schnee M, Soulard F, Gagne K, Bonneville F, Muller JY, Bachner L, Férec C (1996). "The hereditary pancreatitis gene maps to long arm of chromosome 7". Hum. Mol. Genet. 5 (4): 549–54. PMID 8845851.
- ↑ Pandya A, Blanton SH, Landa B, Javaheri R, Melvin E, Nance WE, Markello T (1996). "Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q". Genomics. 38 (2): 227–30. doi:10.1006/geno.1996.0620. PMID 8954806.