Hemophilia A risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahd Yunus, M.D. [2] Vahid Eidkhani, M.D.
Overview
Risk factors for development of Hemophilia A and B include being of male sex and having a positive family history of the disease.
It is of note that acquired forms of the disease occur in specific circumstances including Malignancies, Pregnancy, Autoimmune disorders, Certain medications; All of which could be considered as Hemophilia risk factor either.
Risk Factors
Common risk factors in the development of Hemophilia A are:
Best-studied risk factors of the acquired form of the disease include:[2][3][4]
- Malignancies (mostly hematologic)
- Pregnancy
- Autoimmune disorders(Lupus erythematosus, Rheumatoid arthritis)
- Infections(Hepatitis C, AIDS)
- Certain Drugs consumption (e.g. Interferon-ą)
- Dermatological conditions(Pemphigus, Psoriasis)
Of note, the majority of reported acquired cases of Hemophilia are about Hemophilia A type. It appears that, the same as hereditary form, acquired form of Hemophilia B is rarer than Hemophilia A too.
The remaining cases of acquired Hemophilia are idiopathic or the underlying etiology is not known yet.
References
- ↑ How Hemophilia is Inherited | Hemophilia | NCBDDD | CDC. Available at http://www.cdc.gov/ncbddd/hemophilia/inheritance-pattern.html. Accessed on Sept 20, 2016
- ↑ Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L; et al. (2012). "Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)". J Thromb Haemost. 10 (4): 622–31. doi:10.1111/j.1538-7836.2012.04654.x. PMID 22321904.
- ↑ Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA; et al. (2017). "Acquired hemophilia A: Updated review of evidence and treatment guidance". Am J Hematol. 92 (7): 695–705. doi:10.1002/ajh.24777. PMID 28470674.
- ↑ Collins P, Baudo F, Huth-Kühne A, Ingerslev J, Kessler CM, Castellano ME et al. (2010) Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 3 ():161. DOI:10.1186/1756-0500-3-161 PMID: 20529258