Hemolytic disease of the newborn laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Laboratory Findings

  • Kell system
    • Anti-Kell hemolytic disease of the newborn
      • Anti-K 1 antibodies - disease ranges from mild to severe - over half of the cases are caused by multiple blood transfusions - is the second most common form of severe HDN
      • Anti-K 2 ,anti-K 3 and anti-K 4 antibodies - rare
  • Other blood group antibodies (Kidd, Lewis, Duffy, MN, P and others).

The diagnosis of HDN is based on history and laboratory findings:

Blood tests done on the newborn baby

  • Positive direct Coombs test (might be negative after fetal interuterine blood transfusion)

Blood tests done on the mother

References

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