Guanylate cyclase activator

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A guanylate cyclase activator (or "GUCA") is one of group of proteins which upregulates guanylate cyclase.

It is also known as "guanylate cyclase-activating protein", with the abbreviation "GCAP".

Mutations can be associated with vision defects.[1]

There are five genes involved:


  1. Payne AM, Downes SM, Bessant DA; et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. PMID 9425234.

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