Glucose 1-dehydrogenase

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In enzymology, a glucose 1-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)+ D-glucono-1,5-lactone + NAD(P)H + H+

The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Other names in common use include D-glucose dehydrogenase (NAD(P)+), and hexose phosphate dehydrogenase. This enzyme participates in pentose phosphate pathway.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
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  • K, Rick W, Staudinger HJ (1975). "[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]". Z. Klin. Chem. Klin. Biochem. 13: 101&ndash, 7. PMID 810982.
  • Brink NG (1953). "Beef liver glucose dehydrogenase. 1. Purification and properties". Acta Chem. Scand. 7: 1081&ndash, 1089.
  • Pauly HE and Pfleiderer G (1976). "D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure". Hoppe-Seyler's Z. Physiol. Chem. 356: 1613&ndash, 1623.
  • STRECKER HJ, KORKES S (1952). "Glucose dehydrogenase". J. Biol. Chem. 196: 769&ndash, 84. PMID 12981017.
  • Thompson RE, Carper WR (1970). "Glucose dehydrogenase from pig liver. I. Isolation and purification". Biochim. Biophys. Acta. 198: 397&ndash, 406. PMID 4392298.

External links

The CAS registry number for this enzyme class is 9028-53-9.

Gene Ontology (GO) codes