Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase

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In enzymology, a glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

6-(D-glucose-1-phospho)-D-mannosylglycoprotein + H2O alpha-D-glucose 1-phosphate + D-mannosylglycoprotein

Thus, the two substrates of this enzyme are 6-(D-glucose-1-phospho)-D-mannosylglycoprotein and H2O, whereas its two products are alpha-D-glucose 1-phosphate and D-mannosylglycoprotein.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase. This enzyme is also called alpha-glucose-1-phosphate phosphodiesterase.


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  • Srisomsap C, Richardson KL, Jay JC, Marchase RB (1989). "An alpha-glucose-1-phosphate phosphodiesterase is present in rat liver cytosol". J. Biol. Chem. 264: 20540&ndash, 6. PMID 2555363.

External links

The CAS registry number for this enzyme class is 123940-44-3.

Gene Ontology (GO) codes