Glucosamine-1-phosphate N-acetyltransferase

In enzymology, a glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + alpha-D-glucosamine 1-phosphate <math>\rightleftharpoons</math> CoA + N-acetyl-alpha-D-glucosamine 1-phosphate

Thus, the two substrates of this enzyme are acetyl-CoA and alpha-D-glucosamine 1-phosphate, whereas its two products are CoA and N-acetyl-alpha-D-glucosamine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2OI5, 2OI6, and 2OI7.

References

• Mengin-Lecreulx D, van Heijenoort J (1994). "Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis". J. Bacteriol. 176: 5788&ndash, 95. PMID 8083170.