Gluconate 5-dehydrogenase

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In enzymology, a gluconate 5-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

D-gluconate + NAD(P)+ 5-dehydro-D-gluconate + NAD(P)H + H+

The 3 substrates of this enzyme are D-gluconate, NAD+, and NADP+, whereas its 4 products are 5-dehydro-D-gluconate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD(P)+ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VL8.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Ameyama M and Adachi O (1982). "5-Keto-D-gluconate reductase from Gluconobacter suboxydans". Methods Enzymol. 89: 198&ndash, 202.
  • Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726&ndash, 32. PMID 16526094.
  • Okamoto K (Tokyo). "Enzymic studies on the formation of 5-ketogluconic acid by Acetobacter suboxydans. II. 5-Ketogluconate reductase". J. Biochem.: 448. Check date values in: |date= (help)

External links

The CAS registry number for this enzyme class is 9028-70-0.

Gene Ontology (GO) codes