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Gliosis is a proliferation of astrocytes in damaged areas of the central nervous system (CNS). Astrocytes are relatively large glial cells and have various functions, including accumulating in areas where neurons have been damaged. Gliosis and neuronal loss in certain brain regions are findings seen in various neurodegenerative disorders such as Alzheimer's disease, Korsakoff's syndrome, multiple system atrophy, prion disease and AIDS dementia complex. It can also be found in Parkinson's disease.