Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Hnatyszyn HJ, Liu M, Hilger A, Herbert L, Gomez-Fernandez CR, Jorda M, Thomas D, Rae JM, El-Ashry D, Lippman ME (2010). "Correlation of GREB1 mRNA with protein expression in breast cancer: Validation of a novel GREB1 monoclonal antibody". Breast Cancer Research and Treatment. 122 (2): 371–80. doi:10.1007/s10549-009-0584-x. PMID19842031.
Deschênes J, Bourdeau V, White JH, Mader S (2007). "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences". Journal of Biological Chemistry. 282 (24): 17335–9. doi:10.1074/jbc.C700030200. PMID17463000.
Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2012). "The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis". Fertility and Sterility. 98 (5): 1200–8. doi:10.1016/j.fertnstert.2012.06.056. PMID22884659.
Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ, Lippman ME (2006). "GREB1 is a novel androgen-regulated gene required for prostate cancer growth". The Prostate. 66 (8): 886–94. doi:10.1002/pros.20403. PMID16496412.
Rittié L, Kang S, Voorhees JJ, Fisher GJ (2008). "Induction of collagen by estradiol: Difference between sun-protected and photodamaged human skin in vivo". Archives of Dermatology. 144 (9): 1129–40. doi:10.1001/archderm.144.9.1129. PMID18794456.
Ghosh MG, Thompson DA, Weigel RJ (2000). "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer". Cancer Research. 60 (22): 6367–75. PMID11103799.