GDP-6-deoxy-D-talose 4-dehydrogenase

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In enzymology, a GDP-6-deoxy-D-talose 4-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-talose + NAD(P)+ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+

The 3 substrates of this enzyme are GDP-6-deoxy-D-talose, NAD+, and NADP+, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase. This enzyme is also called guanosine diphospho-6-deoxy-D-talose dehydrogenase. This enzyme participates in fructose and mannose metabolism.


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  • Markovitz A (1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose". J. Biol. Chem. 239: 2091&ndash, 2098.

External links

The CAS registry number for this enzyme class is 37250-66-1.

Gene Ontology (GO) codes